Synthesis of the 6-Substituted Imidazo[1,2-a]Pyridine-3-yl-2- Phosphonopropionic Acids as Potential Inhibitors of Rab Geranylgeranyl Transferase

Twelve phosphonopropionates derived from 2-hydroxy-3-imidazo[1,2- a ]pyridin-3- yl -2-phosphonopropionic acid (3-IPEHPC) were synthesized and evaluated for their activity as inhibitors of protein geranylgeranylation. The nature the substituent in C6 position imidazo[1,2- ]pyridine ring was responsible compound's against Rab geranylgeranyl transferase (RGGT). most active disrupted Rab11A prenylation human cervical carcinoma HeLa cell line. esterification carboxylic phosphonopropionate moiety turned inhibitor into an inactive analog.